ABSTRACT
Objective: To evaluate the positive and negative predictive value of the positive family history of G6PD in predicting the actual G6PD of newborns compared to the mean total serum bilirubin [TSB] level for one-week
Design: A Prospective Study
Setting: Salmaniya Medical Complex and Jidhafs Maternity Hospital, Bahrain
Method: The mothers filled a survey, and the newborns underwent serum bilirubin check during the first week of life [day one, day two to four and day five to seven]. The G6PD activity status was tested as part of the newborn screen for all the newborns in Bahrain
Result: Four hundred twenty-seven newborns were included in the study; males were 219 [51.3%]. Two hundred eighty-eight [67.4%] of the newborns had G6PD normal activity and 139 [32.6%] were G6PD deficient. Two hundred fifty-one [58.8%] had a positive family history of G6PD deficiency while 176 [41.2%] did not have a family history of G6PD deficiency. The positive predictive value [PPV] for family history of G6PD deficiency is 47.4%, while the negative predictive value [NPV] is 89.1%. The mean serum bilirubin level for newborns with G6PD reduced activity was 139 +/- 52 micro mol/L. The serum bilirubin level was higher if the previous sibling required phototherapy, 157 micro mol/L +/- 50 micro mol/L [P-value<0.001]
Conclusion: Family history could be helpful for clinicians but it should be considered with caution. The negative predictive value is 89.1%, which means that 20 [4.7%] of the newborns had no family history of G6PD deficiency and still have G6PD deficiency
ABSTRACT
Objective: To evaluate the course of jaundice in newborns with G6PD reduced activity compared to G6PD normal activity
Design: A Prospective Study
Setting: Salmaniya Medical Complex and Jidhafs Maternity Hospital, Bahrain
Method: This is a prospective study on newborns from May to September of 2015. Total Serum Bilirubin [TSB] was measured from day one of life to day seven for all neonates. G6PD activity was documented from the records
Results: One hundred twenty-five children were included in the study; 71 [56.8%] were newborns with normal G6PD activity and 54 [43.2%] were G6PD reduced activity. The mean TSB was significantly higher in newborns with G6PD reduced activity 11.23 +/- 3.50 mg/dl compared to newborns with G6PD normal activity 9.52 +/- 4.16 mg/dl [P-value 0.001]
The mean TSB on day one for newborns with G6PD reduced activity was higher compared to newborns with G6PD normal activity; 6.37 +/- 6.76 mg/dl and 1.82 +/- 1.94 mg/dl respectively [P-value 0.078]
Conclusion: The course of hyperbilirubinemia in children with G6PD reduced activity was different compared to children with G6PD normal activity. The mean TSB was significantly higher in newborns with G6PD reduced activity. A bilirubin level of 6mg/dl during the first neonatal day could be an indicator for the presence of G6PD reduced activity in the newborn
ABSTRACT
Objective: To evaluate the relation between the transcutaneous bilirubin [TcB] measurement and the total serum bilirubin [TSB] measurement in the newborns in Bahrain. Setting: Salmaniya Medical Complex and Jidhafs Maternity Hospital, Bahrain. Design: A Prospective Study
Method: Newborns from May to September 2015 were included in the study. Serial transcutaneous bilirubin [TcB] measurements were obtained utilizing the Drager Jaundice Meter JM-103. Simultaneously, TSB measurements were performed for comparison
Result: Eighty-eight newborns were included. One hundred twenty-eight transcutaneous bilirubin TcB measurements were paired with TSB measurement. The mean +/- SD of [TcB-TSB] difference for the 128 paired measurements was 1.09 +/- 2.16 mg/dL, with differences ranging from 6.18 mg/ dL to 7.00 mg/dL. The correlation between the paired measurements was 0.75 [P-value < 0.0005]
Conclusion: TcB measurement is a viable tool for bilirubin screening in newborns